Novel Markers for Diagnosis and Prognosis of Oral Intraepithelial Neoplasia
نویسندگان
چکیده
Squamous carcinoma of the oral cavity is a slow multi-steps process, based on progressive accumulation of genetic events leading to the selection of clonal populations of transformed epithelial cells (Ha&Califano, 2002) The spectrum of histological changes occurring in this process ranges from atypical squamous hyperplasia to carcinoma in situ (CIS), and is grouped under the designation of oral intraepithelial lesions (OILs) (Gale et al, 2005; Gale et al 2006). In their evolution, most cases of OILs are self-limiting and reversible, whereas some persist and may progress to SCC in spite of careful follow-up and treatment (Kambicˇ&Gale, 1986; Crissman et al, 1993).
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